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与亚临床甲状腺功能低下症相关的脂质谱扰乱:一项描述性研究
Sara Harrar1, Ibtissam Mhirig1, Yazid El Alaoui Boufares1
1Department of Clinical Biochemistry, Mohamed VI Training and Research Hospital, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, MAR.
亚临床甲状腺功能低下症 (SCH) 影响着超过12%的人口,与更高的脂质失调症患病率有关,增加了心血管风险. 患有SCH的个体患有失脂血症的可能性是1.5倍.
科学领域:
- 内分泌学 在内分泌学.
- 临床生物化学 临床生物化学
- 评估心血管风险评估
背景情况:
- 甲状腺功能低下症是一种常见的内分泌疾病.
- 脱脂症是一种脂质代谢异常,显著增加心血管风险.
- 亚临床甲状腺功能障碍症 (SCH) 是明显甲状腺功能障碍症的前体,其特征是甲状腺刺激激素 (TSH) 的升高与正常的自由甲状腺素 (FT4) 水平.
研究的目的:
- 为了确定多样化的摩洛哥人口中脱脂症和SCH的患病率.
- 为了调查SCH和脂质不良症之间的关联.
- 评估SCH对脂质样本的影响.
主要方法:
- 一个描述性的,横截面的,对447名患者的回顾性分析.
- 从一所大学医院的临床生物化学系收集了超过19个月的数据.
- 使用Cobas Roche® 6000系统进行标准化脂质概况和TSH测量.
主要成果:
- 脱脂症的总体患病率为42.05%,其中低高血脂症是最常见的 (31.31%).
- SCH患病率为12.75%,主要在女性中.
- 失脂症的患病率在SCH组中较高 (50.87%),相比于euthyroid组 (40.76%),在SCH组中增加过高甘油三和低高血. 在SCH和脂质不良症之间发现了显著的关联 (p < 0.05).
结论:
- 亚临床的甲状腺功能低下症与更高的血脂障碍的患病率有关.
- 在患有SCH.的个体中,低高血糖血和高三糖血更常见.
- 早期发现和管理SCH可能对降低心血管风险至关重要.
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