在呈现时检测到的病毒性病是奇孔古尼亚疾病严重程度的预测指标
Sumit K Rawat1,2, Dipesh Kale2, Shashwati Nema2
1Microbiology, Bundelkhand Medical College, Sagar, IND.
Cureus
|May 14, 2024
概括
通过RT-PCR检测奇孔古尼亚病毒 (CHIKV) 病毒病与严重疾病有关. 早期检测病毒病和老年可能会预测严重的 Chikungunya 结果,有助于更密切地监测患者.
科学领域:
- * 传染病 传染病
- * 病毒学 病毒学
- * 临床医学 临床医学
背景情况:
- * Chikungunya是一种重新出现的蚊子传播疾病,在全球引起疫情.
- *严重的,使人衰弱的疾病发生在很大一部分感染者身上.
- * 临床上需要早期识别那些易患重度奇昆古尼亚的人.
研究的目的:
- * 调查可检测的病毒性血清与严重的 Chikungunya 疾病之间的关联.
- * 确定奇孔古尼亚患者严重结局的临床预测因素.
- * 评估RT-PCR阳性作为疾病严重程度指标的有用性.
主要方法:
- *对1021名疑似 Chikungunya 患者进行前性观察研究,病发7天内出现.
- *使用 Chikungunya Virus IgM ELISA 的查,然后对IgM阳性病例进行RT-PCR.
- *根据症状持续时间 (超过两周的轻度与严重程度) 进行疾病严重程度的分类.
主要成果:
- *发现了178 (17.4%) 实验室确诊的奇昆古尼亚病例;31 (18.9%) 被归类为严重.
- *可检测的病毒性血清 (RT-PCR阳性) 在16名 (9%) 患者中发现,与严重疾病的更高几率相关 (OR=4.1).
- *严重病例显示RT-PCR阳性的比例明显高 (25.8%),相比轻度病例 (5.5%). 老年人 (>60岁) 患重病率较高.
结论:
- *在奇孔古尼亚病毒 (CHIKV) 患者中检测到的病毒性血与严重疾病的风险增加有关.
- * 在严重的 Chikungunya 病例中,呈现时的 RT-PCR 阳性显著更高.
- * 病毒病,关节症状和老年是潜在的临床预测因素,可以更密切地监测小孔古尼亚患者.
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