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相关概念视频

Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
Self-Discrepancy Theory02:45

Self-Discrepancy Theory

One influential perspective on what motivates people's behavior is detailed in Tory Higgin's self-discrepancy theory (Higgins, 1987). He proposed that people hold disagreeing internal representations of themselves that lead to different emotional states.
Deindividuation00:57

Deindividuation

Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.

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相关实验视频

Updated: Jun 16, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus
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德科维里马的不洁性研究.

Emmanuel Mintah Bonku1,2, Hongjian Qin1,3, Abdullajon Odilov1,2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, PR China.

Heliyon
|May 14, 2024
PubMed
概括

这项研究详细介绍了对tecovirimat的杂质控制,这是一种针对水的抗病毒药物. 有效的方法确保高质量的药物制造,符合全球制药标准.

关键词:
遗传毒性杂质 是一种污染物.国际协调会议 (ICH) 国际协调会议过程开发 过程开发质量控制 质量控制德科维里马特的使用方法

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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Last Updated: Jun 16, 2026

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科学领域:

  • 制药制造业 制药制造业 制药制造业
  • 分析化学 分析化学
  • 抗病毒药物开发 抗病毒药物开发

背景情况:

  • 德科维里马特是治疗水的关键抗病毒药物.
  • 确保药物的纯度和安全性在制药生产中至关重要.
  • 工艺和基因毒性杂质需要严格的识别和控制.

研究的目的:

  • 在tecovirimat制造过程中系统地识别,合成和控制杂质.
  • 建立符合ICH标准的tecovirimat药物质量标准.
  • 为了评估商业样品和大规模生产的杂质控制.

主要方法:

  • 关键杂质的合成.
  • 使用核磁共振 (NMR) 分析进行结构确认.
  • 染色学和质谱技术 (GC,HPLC-MS) 的使用.

主要成果:

  • 建立了一种用于杂质识别和控制的综合方法.
  • 证实了关键杂质的化学结构.
  • 对于商业样品和高达60公斤的批量大小,有效的杂质控制被证明是有效的.

结论:

  • 这项研究为tecovirimat生产中的杂质表征和控制提供了坚实的框架.
  • 遵守ICH标准可以确保tecovirimat药物质量的质量和安全性.
  • 这项工作是首次评估tecovirimat制造过程中的过程和基因毒性杂质.