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Updated: Jun 26, 2025

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
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可注射温度敏感的水凝,促进内镜下膜剖析.

Ruifen Xu1, Xiaoyu Yang2, Tong Yi2

  • 1Anesthesiology Department, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.

Frontiers in bioengineering and biotechnology
|May 14, 2024
PubMed
概括

一种新型的FS水凝,由聚乙烯-聚乙烯甘醇和氨酸盐制成,为内镜粘膜剖析 (ESD) 提供安全,经济有效和持久的粘膜下注射溶液. 与传统方法相比,这种材料提供了更高的粘膜提升.

关键词:
进行内镜粘膜剖析.的胃肠道瘤.这是一种水凝.粘膜上升的升高情况在 submucosal 的注射.

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科学领域:

  • 生物材料科学 生物材料科学
  • 胃肠病学 胃肠病学
  • 内視鏡外科手術 內視鏡外科手術

背景情况:

  • 对于早期胃肠道瘤,内镜粘膜解剖 (ESD) 需要注射粘膜下液体以提高粘膜的升高.
  • 目前使用正常盐水的方法提供短暂的升高,需要重复注射并增加程序时间.
  • 现有的下注射材料 (SIM) 在制备,成本和生物相容性方面面临挑战.

研究的目的:

  • 开发和评估一种新型的粘膜下注射材料,以改善ESD期间的粘膜升高.
  • 解决当前SIM的局限性,包括时间短,不便和生物相容性差.

主要方法:

  • 通过混合聚乙烯-聚乙烯甘醇 (F-127) 与藻酸盐 (SA) 合成的FS水凝.
  • 描述FS水凝的物理化学特性和生物安全性评估.
  • 通过体外下注射和体内猪ESD评估FS水凝的性能.

主要成果:

  • FS水凝在室温下是液体,易于注射,并经过温度诱导的凝,在粘膜下形成固态.
  • 显示可控制的凝,稳定性和良好的生物相容性.
  • 在体外和体外ESD模型中实现了高,持久的粘膜增大和有效的粘膜下缓冲.

结论:

  • F-127/SA水凝为下注射提供了一个简单,经济有效,安全和稳定的替代方案.
  • 该FS水凝有效地支持ESD程序,为当前的下注射材料提供了理想的替代品.