用于监管用途评估发育和成人神经毒性的新方法方法:一个PARC工作包5项目的项目
Tamara Tal1,2, Oddvar Myhre3, Ellen Fritsche4,5,6
1Helmholtz Centre for Environmental Research - UFZ, Chemicals in the Environment Research Section, Leipzig, Germany.
Frontiers in toxicology
|May 14, 2024
概括
新方法方法 (NAMs) 为化学神经毒性评估提供了对动物试验的经济有效和道德替代方案. 国家监管机制旨在为监管风险评估提供可靠,快速和信息化的工具.
科学领域:
- 环境毒理学环境毒理学
- 监管科学是一种监管科学.
- 在体外毒理学.
背景情况:
- 在欧洲,动物体内研究是神经毒性评估的首要依据,但这些研究成本昂贵,并且在道德上受到争议.
- 社会需求和监管倡议推动用体外和替代方法取代动物模型.
- 许多化学物质缺乏全面的神经毒性评估,突出了先进方法的需要.
研究的目的:
- 开发和评估用于发育神经毒性 (DNT) 和成人神经毒性 (ANT) 的新方法 (NAM).
- 了解NAM用于检测内分泌干扰和表观遗传干扰的应用领域.
- 创建下一代,监管准备好的危险和风险评估工具,这些工具是强大的,快速的,和成本效益.
主要方法:
- 识别晚期发作的神经毒性影响的早期指标,以加快检测时间和降低成本.
- 在化学品风险评估欧洲伙伴关系 (PARC) 的框架内开发和评估NAM.
- 与监管机构合作,确保NAM在监管接受方面的相关性和可靠性.
主要成果:
- 专注于识别早期的指标,以加快测试后期出现的影响.
- 为DNT和ANT开发特定的NAM,包括对内分泌干扰和表观遗传干扰的评估.
- 第二代DNT和第一代ANTT测试电池的组装.
结论:
- 在现代化化化学品安全评估和满足监管要求方面,NAMs至关重要.
- 该PARC倡议旨在克服实施神经毒性NAM的挑战.
- 开发的测试电池将为利益相关者提供更好的危险和风险评估工具.
关键词:
这是一个DNT-IVBB.成年人的神经毒性 (ANT)适用性领域 (applicability domain) 是一个应用领域.发展神经毒性 (DNT)新方法方法 (NAM)斑马鱼是一种斑马鱼.更多相关视频
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