患有囊性纤维化症的儿童的阻塞性睡眠呼吸暂停在高度有效的调节器治疗中
Aarti Shakkottai1, Stephany Kim2, Ron B Mitchell3
1Department of Pediatrics, Division of Pediatric Pulmonology and Sleep Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
阻塞性睡眠呼吸暂停 (OSA) 在患有囊性纤维化 (CF) 的儿童中很常见,即使在高效调制剂疗法 (HEMT) 后也是如此. 接受HEMT治疗的儿童年龄较大,更有可能患有OSA,这表明继续需要查.
科学领域:
- 儿科肺病学 儿科肺病学
- 睡眠医学 睡眠医学
- 囊性纤维化研究 囊性纤维化研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是儿科囊性纤维化 (CF) 患者已知的并发症.
- 高效调节器疗法 (HEMT) 改善了CF的结果,但它们对OSA频率的影响尚不清楚.
研究的目的:
- 在HEMT后的时代,确定CF儿童的OSA频率.
- 在这个人群中评估HEMT使用和OSA之间的关联.
主要方法:
- 从2012年至2023年期间,对49名患有CF的儿童 (0-18岁) 进行了多睡眠记录 (PSG) 数据的回顾性审查.
- 患者根据HEMT状态被分类.
- 使用后勤回归分析来评估HEMT和OSA之间的关联.
主要成果:
- 在研究的儿童中,57%的儿童被诊断出OSA.
- 接受HEMT的儿童年龄较大,患OSA的几率明显更高 (OR=4.3,p=0.02).
- 桃体缩也独立地与增加OSA的几率相关 (OR=6.6,p=0.03).
结论:
- 即使在引入HEMT后,OSA仍然是患有CF的儿童的常见诊断.
- 虽然HEMT使用与年龄较大和OSA更高的可能性有关,但肺功能和营养状况等关键健康指标在各组之间相似.
- 进一步的前性研究是有必要的,以充分阐明儿童CF患者中HEMT和OSA之间的关系.
更多相关视频
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
07:04Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
Published on: February 11, 2017
相关概念视频
Cystic Fibrosis: Management
Sinus disease and chronic...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
COPD: Management Using Bronchodilators and Corticosteroids
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
