相关实验视频
Updated: Jun 26, 2025
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
1.6K
[具有DICER1突变的成年甲状腺瘤的临床病理特征]
1Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Zhonghua yi xue za zhi
|May 14, 2024
概括
在27%的甲状腺瘤中发现了DICER1基因突变,主要在年轻女性中. 这些瘤很大,BRAF V600E野生型,预后很好,需要进一步的遗传检测.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 病理学 病理学 病理学
背景情况:
- DICER1基因突变与各种癌症有关.
- 甲状腺结节需要准确的诊断和分子分析.
研究的目的:
- 研究甲状腺瘤中DICER1基因突变的流行率和特征.
- 确定甲状腺瘤中DICER1和BRAF V600E突变之间的关系.
- 为了将临床病理特征与DICER1突变状态相关联.
主要方法:
- 桑格测序用于检测37例甲状腺瘤病例中的DICER1和BRAF V600E基因突变.
- 超声波,组织病理学和免疫组织化学被用来进行表征.
- 进行了随访,以评估预后.
主要成果:
- 在27%的病例中 (10/37) 发现了DICER1突变,仅在女性中 (平均年龄为38.0岁).
- 所有DICER1突变瘤都是BRAF V600E野生型,显示出明显的超声波和病理特征 (封装,富含合物,大卵泡).
- 瘤大小平均为3.68厘米,Ki67指数为2-10%;在随访期间没有观察到复发或转移.
结论:
- 在这些甲状腺瘤中,DICER1和BRAF V600E突变相互排斥.
- DICER1突变的甲状腺瘤较大,发生在年轻女性身上,并且有良好的预后.
- 对于疑似病例,建议对DICER1进行分子检测,建议进行生殖线检测以排除DICER1综合征.
相关概念视频
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K