ApTOLL:一种用于多发性硬化症后细胞保护和 (重新) 髓化的一种新型治疗性吸收体
Beatriz Fernández-Gómez1,2,3, Miguel A Marchena1,4,5, David Piñeiro2
1Instituto Cajal-CSIC, Madrid, Spain.
British journal of pharmacology
|May 14, 2024
概括
阿普托尔 (ApTOLL) 是一种向收费类受体4 (TLR4) 的阿普托尔,显示出对多发性硬化症 (MS) 治疗有前景. 它减少了炎症并促进了动物模型中的髓修复,这表明了MS的新治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 收费类受体4 (TLR4) 在先天性免疫和与多发性硬化症 (MS) 相关的炎症反应中起着关键作用.
- 目前的多发性硬化症治疗主要集中在免疫调节上,缺乏促进复髓化的药物.
- ApTOLL是一种aptamer,旨在对抗TLR4活性.
研究的目的:
- 在MS的动物模型中研究ApTOLL的治疗潜力.
- 评估ApTOLL对炎症,脱髓化和复髓化过程的影响.
主要方法:
- 利用实验性自身免疫脑膜炎 (EAE) 模型来评估抗炎作用.
- 采用了cuprizone模型和初级寡类细胞前体细胞 (OPC) 培养物 (小鼠和人类) 来评估对寡类细胞和复髓化的直接影响.
- 在脱髓化脑组织的ex vivo器官类型培养物中研究的效果.
主要成果:
- 在EAE和cuprizone模型中,ApTOLL治疗显著改善了临床症状.
- 观察到在脱髓化病变中增强了髓的保存和恢复.
- 在纯化的动物和人类OPC培养物中确认了复髓化作用.
结论:
- ApTOLL既具有抗炎性,也具有复髓化特性,为MS提供了一种新的治疗方法.
- 胺体表现出神经保护性和恢复性作用对寡细胞.
- 已建立的ApTOLL安全概况支持其在MS患者的临床试验中取得进展.
更多相关视频
06:07Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System
Published on: December 17, 2021
4.8K
10:46A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
3.6K
相关概念视频
01:27Transducer Mechanism: Enzyme-Linked Receptors
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
01:06Carrier-Mediated Transport
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
01:16Transduction
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...