NIR和磁力双响应多核磁纳米花用于增强磁光热癌症治疗
Kaiming Shen1, Lixian Li2, Funan Tan3
1Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing 400044, China. yunfeiyan@cqu.edu.cn.
Nanoscale
|May 14, 2024
概括
新的MnZnFe2O4纳米花与圆形核心增强磁光热疗法. 这些纳米剂显示改善了加热效率,并显著降低了癌细胞活力,以有效治疗瘤.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 对纳米剂而言,磁性高温和光热疗法的效率是有限的.
- 域磁纳米粒子提供了增强的性能和生物相容性.
研究的目的:
- 开发新的Mn0.5Zn0.5Fe2O4 (MZF) 纳米花与圆形核心,用于协同磁光热疗法.
- 与其他MZF纳米结构相比,评估它们的有效性.
主要方法:
- 合成了各种形状的MZF纳米粒子 (纳米立方体,空心球体,具有圆形/针状核心的纳米花).
- 评估了磁性高温 (MHT) 的加热性能,包括内在损失参数 (ILP).
- 测量了光热转换效率 (PTC).
- 进行了微磁模拟,用于磁化分析.
- 在BT549,MCF-7和4T1细胞上进行了体外细胞活力测定.
主要成果:
- 带有圆形核心的MZF纳米花 (MZF-NFE) 显示出高ILP15.3Nh m2 kg-1,超过了商业等价物.
- 所有纳米结构都实现了超过18%的PTC率.
- 使用MZF-NFE的组合MHT和PTT在体外减少了~95.7%的癌细胞活力.
结论:
- MZF-NFE纳米剂在磁光热协同疗法中非常有效.
- 圆形核心结构优化了磁性加热特性.
- 这些发现为晚期癌症高温治疗提供了有希望的策略.
相关概念视频
Force On A Current Loop In A Magnetic Field
Magnetic forces on wires carrying current are most frequently applied in motors. A DC motor is a device that converts electrical energy into mechanical work. In motors, wire loops are enclosed in a magnetic field. When current flows through the loops, the magnetic field applies torque, which causes the shaft to rotate. The direction of the current is reversed once the loop's surface area is lined up with the magnetic field, causing a constant torque on the loop. During the process, commutators...
Torque On A Current Loop In A Magnetic Field
The most common application of magnetic force on current-carrying wires is in electric motors. These consist of loops of wire, which are placed between the magnets with a magnetic field. When current flows through the loops, the magnetic field applies torque, which causes the shaft to rotate, thus converting electrical energy to mechanical energy.
Consider a rectangular current-carrying loop containing N turns of wire, placed in a uniform magnetic field. The net force on a current-carrying loop...
Consider a rectangular current-carrying loop containing N turns of wire, placed in a uniform magnetic field. The net force on a current-carrying loop...
Magnetic Force Between Two Parallel Currents
Two long, straight, and parallel current-carrying conductors exert a force of equal magnitude on one another. The direction of the force depends on the current direction in the conductors.
The force exerted by the magnetic field due to the first conductor over a finite length of the second conductor is given as the product of the current in the second conductor and the vector product of the length vector along the current element and the field due to the first conductor. According to the...
The force exerted by the magnetic field due to the first conductor over a finite length of the second conductor is given as the product of the current in the second conductor and the vector product of the length vector along the current element and the field due to the first conductor. According to the...
Magnetic Field Of A Current Loop
Consider a circular loop with a radius a, that carries a current I. The magnetic field due to the current at an arbitrary point P along the axis of the loop can be calculated using the Biot-Savart law.
Energy In A Magnetic Field
If a magnetic field is sustained, there must be a current in a closed circuit or loop, implying some energy has been spent in creating the field. If this energy is not dissipated via the circuit's resistance, it is stored in the field.
Take an ideal inductor with zero resistance. Although it's practically impossible, assume that the coil's resistance is so small that it is practically negligible. The loss of the field's energy to dissipate thermal energy (or heat) is thus negligible.
The energy...
Take an ideal inductor with zero resistance. Although it's practically impossible, assume that the coil's resistance is so small that it is practically negligible. The loss of the field's energy to dissipate thermal energy (or heat) is thus negligible.
The energy...
Magnetic Flux
The magnetic flux measures the number of magnetic field lines passing through a given surface area. The SI unit for magnetic flux is the weber (Wb). Magnetic flux is a scalar quantity. It depends on three factors: the strength of the magnetic field B, the area through which the field lines pass, and the relative orientation of the field with the surface area.
Suppose a surface is divided into elements of area dA. For each element, the component of the magnetic field that is normal to the...
Suppose a surface is divided into elements of area dA. For each element, the component of the magnetic field that is normal to the...


