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Updated: May 9, 2026

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银纳米颗粒嵌入碳化物:对白虫的抗真菌活性和对动物细胞的毒性

Ganeshkumar Arumugam1,2, Sivaraj Durairaj3,4, Juliana Caparroz Gonçale1

  • 1Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo 12245-000, Brazil.

ACS applied materials & interfaces
|May 14, 2024
PubMed
概括

嵌入银的碳化物 (Ag@g-CN) 对Candida albicans表现出强大的抗真菌活性,为口腔感染提供了一个有前途的新疗法. 这种纳米材料在临床前模型中证明了有效性和安全性.

关键词:
2D 材料是二维材料.在C. albicans中,它是最常见的.它具有抗真菌的特性.生物相容性 生物相容性碳化物碳化物一个的热聚合.

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...