俄罗斯左心室缩症老年患者中ATTR-粉症患病率的初级数据
T V Nikiforova1, K V Charaya1, D Yu Shchekochikhin2
1Sechenov First Moscow State Medical University, Moscow.
Kardiologiia
|May 14, 2024
概括
粉样性心肌病 (CM) 影响20%的老年人,心脏壁厚. 在这个患者群体中确诊了转氨基粉症 (ATTR) 和轻链氨基粉症 (AL).
科学领域:
- 心脏病学 心脏病学
- 核医学是一种核医学.
- 血液学 血液学 血液学
背景情况:
- 粉样性心肌病变 (CM) 是一种渐进的疾病.
- 晶氨基粉症 (ATTR) 和轻链氨基粉症 (AL) 是CM的主要原因.
- 腹腔间隔膜 (IVS) 缩是CM中常见的发现.
研究的目的:
- 为了确定ATTR-CM和AL氨基粉症的患病率.
- 对于65岁以上的患者,IVS缩≥14毫米的患者来研究这些情况.
主要方法:
- 招募了60名 (>65岁) 患有IVS缩的患者.
- 使用心声回声学,心肌扫描 (99mTc-pyrofotech),SPECT,生物标志物分析 (NT-proBNP,热素I) 和血清/尿液蛋白质电泳.
- 进行了ATTR亚型 (wtATTR,hATTR) 的遗传研究,如果通过光学图表示的话.
主要成果:
- 在20% (12/60) 的患者中检测到粉样体CM.
- 在11.7% (7/60) 的病例中发现了ATTR氨基粉症.
- 在8.3% (5/60) 的病例中发现了AL氨基粉症.
结论:
- 粉样CM在患有IVS缩的老年人中普遍存在.
- ATTR和AL氨基粉症是显著的贡献者.
- 通过成像和生物标志物进行早期检测至关重要.
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