最近机器学习方法的进展,用于预测药物开发中的致癌性.
Nguyen Quoc Khanh Le1,2,3,4, Thi-Xuan Tran5, Phung-Anh Nguyen6,7
1Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Expert opinion on drug metabolism & toxicology
|May 14, 2024
概括
机器学习 (ML) 正通过改善致癌性预测来彻底改变药物开发. 这种方法提高了安全性评估,克服了传统方法的局限性,使药物发现更加有效和准确.
科学领域:
- 药理学 药理学是指药理学的学科.
- 计算毒理学计算毒理学
- 药物开发 药物开发
背景情况:
- 传统的致癌性预测方法 (体内,体外测试) 是资源密集型的,并且有局限性.
- 药物开发在准确和有效的安全评估方面面临挑战.
- 机器学习 (ML) 为这些挑战提供了一种变革性的方法.
研究的目的:
- 审查ML对药物开发中的致癌性预测的影响.
- 探索ML,深度学习和AI在药物安全性评估中的整合.
- 突出ML在克服传统方法局限性的作用.
主要方法:
- 审查关于ML在药物开发安全中的应用现有文献.
- 传统致癌性评估技术的分析.
- 在预测毒理学中探索人工智能和深度学习的整合.
主要成果:
- ML显著提高了致癌性评估中的预测准确性和效率.
- 人工智能和深度学习是适用于从早期查到临床试验的多功能工具.
- ML解决了数据解释,伦理和监管方面的挑战.
结论:
- ML方法正在彻底改变致癌性预测和药物安全性评估.
- 机器学习,深度学习和人工智能的整合为传统方法的局限性提供了创新的解决方案.
- 采用ML对于推动高效和道德的药物开发至关重要.
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