肺,咳和吞功能在患有肌缩性侧面硬化症的个体之间的关系
Cara Donohue1,2, Terrie Vasilopoulos3, James P Wymer4
1Aerodigestive Research Core Laboratory, The Ohio State University, Columbus, Ohio, USA.
Muscle & nerve
|May 14, 2024
概括
肺功能和咳强度与肌缩性侧面硬化症 (ALS) 有关. 减少的呼气强度 (最大呼气压力和最大呼气流量) 与不安全的吞有关,增加了呼吸道保护风险.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 语音语言病理学 语音语言病理学
背景情况:
- 肌缩侧面硬化症 (ALS) 影响呼吸和吞功能.
- 了解肺,咳和吞功能之间的关系对于ALS的疾病管理至关重要.
- 目前存在关于这些关键功能指标在ALS患者的相互关系的知识差距.
研究的目的:
- 研究ALS患者肺功能,咳强度和吞功能之间的关联.
- 为了确定呼吸和咳指标是否与ALS的吞障碍严重程度相关.
主要方法:
- 一百名ALS患者接受了肺功能测试 (FVC,MEP,MIP),自愿咳峰值呼气流量 (PEF) 测量和视频光镜吞评估 (VF).
- 吞功能被评估使用吞毒性动态成像等级 (DIGEST) 尺度由盲目的重复评级者.
- 统计分析包括描述性统计,斯皮尔曼的罗相关性,克鲁斯卡尔-瓦利斯和皮尔森的千平方测试.
主要成果:
- 在肺和咳测量之间发现了显著的正相关性 (例如,MEP-MIP:r=0.76,MIP-PEF:r=0.68,MEP-FVC:r=0.46,所有p<0.0001).
- 缺食症是普遍存在的,其中31%的吞正常,48%是轻微的,10%是中度的,10%是严重的,1%是危及生命的.
- 在具有较高DIGEST等级 (不安全吞) 的个体中,最大呼气压 (MEP) 和峰值呼气流 (PEF) 显着较低.
结论:
- 肺功能和自愿咳强度在患有ALS的个体中显著相关.
- 减弱的呼吸功能 (MEP,PEF) 与ALS患者的吞安全性受损有关.
- 这些发现突显了ALS患者呼吸道保护缺陷的风险,ALS患者的呼吸能力降低和呼吸障碍.
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