在阴茎癌中循环D1的表达
Wesliany Everton Duarte1,2, Jaqueline Diniz Pinho3,4, Syomara Pereira da Costa Melo1,5
1Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil.
Oncotarget
|May 14, 2024
概括
阴茎癌 (PC) 中的环素D1表达与侵略性特征和人类乳头瘤病毒 (HPV) 状态相关. 它的缺席与HPV阳性亚型有关,而存在表明更高的等级和更差的预后,表明作为生物标志物的潜力.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 分子生物学分子生物学
背景情况:
- 阴茎癌 (PC) 是一个重要的健康问题,特别是在某些地区.
- 了解与PC进展相关的分子机制和生物标志物对于改善患者结果至关重要.
- 环素D1是一种细胞循环调节剂,与各种癌症有关.
研究的目的:
- 分析阴茎癌 (PC) 患者中cyclin D1的表达特征.
- 确定循环素D1表达和PC的临床病理学特征之间的相关性.
- 调查cyclin D1作为PC的预后生物标志物的潜力.
主要方法:
- 在2013-2017年期间接受治疗的100名PC患者的回顾性研究.
- 对临床,流行病学和遗传病学数据的分析.
- 使用聚合酶链反应 (PCR) 检测人类乳头瘤病毒 (HPV) DNA.
- 通过免疫组织化学技术评估环素D1的表达.
主要成果:
- 缺少cyclin D1表达与HPV阳性组织学亚型 (p=0.001) 有意义地相关.
- 环素D1表达与高等级瘤 (p=0.014),特定组织学亚型 (p=0.001),类转变 (p=0.04) 和周围神经侵入 (p=0.023) 相相关.
- 具有cyclin D1表达的患者表现出较低无病存活率的趋势,尽管在统计学上并不显著.
结论:
- 环素D1的表达与阴茎癌中的侵略性病理特征有关.
- 缺少cyclin D1是HPV阳性PC亚型的标志物.
- 赛克林D1可能作为预测阴茎癌患者预后较差的潜在生物标志物.
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