刺激-响应性阿普塔默-药物结合物用于向药物输送和可控药物释放
Shanshan Zhu1,2, Huan Gao2,3, Wenyuan Li2,3
1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Advanced healthcare materials
|May 14, 2024
概括
这项研究开发了一种双重向的癌症治疗方法,使用刺激响应的阿帕特默-药物合物 (srApDC). 这种方法增强了瘤细胞内的药物输送和释放,显著提高了癌症治疗的治疗疗效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 化疗疗效率受到低效的抗癌剂输送的限制.
- 不有效的细胞内化和细胞内药物释放阻碍了癌症治疗.
- 目前的积极向或瘤微环境 (TME) 响应策略提供有限的治疗改善.
研究的目的:
- 制定一个双重目标战略,结合主动向和TME响应能力,以加强癌症治疗.
- 构建和评估具有刺激反应的吸收体-药物合体 (srApDCs),用于向药物输送和受控释放.
- 调查srApDCs在提高药物递送效率和治疗结果方面的潜力.
主要方法:
- 结合瘤向性受体 (AS1411) 与使用各种刺激反应链接剂的药物,以创建srApDCs.
- 评估srApDCs的选择性细胞吸收通过aptamer调解.
- 药物释放的评估是由TME内的病理线索引发的.
- 实验验证增强治疗功效的实验验证.
主要成果:
- 阿普塔默成分选择性地增强了srApDCs进入瘤细胞的吸收.
- 刺激-响应链接剂通过TME特定的病理线索在切割时促进药物有效载荷的释放.
- 与单个策略相比,双重目标方法导致治疗疗效显著提高.
- 实验数据验证了srApDCs的设计假设.
结论:
- 响应刺激的阿帕特马-药物合物 (srApDCs) 是癌症治疗的有前途的双重向策略.
- 这种方法通过增强细胞内部化和受控的细胞内释放,有效地提高药物递送效率.
- 开发的方法为改善癌症治疗结果提供了一种新且有效的方法.
更多相关视频
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
6.0K
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.7K
相关概念视频
Targets for Drug Action: Overview
6.2K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.2K
Drug-Receptor Interactions
5.1K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
5.1K
Principles of Drug Action
6.0K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.0K
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Drug-Receptor Bonds
2.8K
Drug-receptor bonds are formed through various chemical forces when drugs interact with target cells. Covalent bonds, strong and irreversible, are exemplified by DNA-alkylating anticancer agents that inhibit cell division. However, such irreversible drug binding lacks selectivity and can modify the DNA of the surrounding healthy cells. Covalent binding often contributes to tissue toxicity, as seen with chloroform and paracetamol metabolites binding to the liver, causing hepatotoxicity.
In...
In...
2.8K
