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相关概念视频

Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
Types of Skeletal Muscle Fibers01:32

Types of Skeletal Muscle Fibers

Skeletal muscles comprise various fibers, each with distinct characteristics and roles in movement and stability. They are mainly categorized into three types — fast-twitch, slow-twitch, and intermediate.
Fast-twitch fibers
Fast-twitch fibers, or Type II fibers, are designed for quick, powerful bursts of speed and strength. They reach peak tension within approximately 0.01 seconds following stimulation. Characterized by a large diameter and densely packed myofibrils, these fibers contain...
Structure and Organization of Smooth Muscles01:13

Structure and Organization of Smooth Muscles

Smooth muscle tissue is a type of muscle tissue that can be found lining various vital organs in the human body, including the lungs, blood vessels, digestive tract, and respiratory tract. This type of tissue is responsible for regulating the movements of these organs, playing crucial roles in the functioning of various systems, including the vascular, digestive, respiratory, and urinary systems.
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...

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相关实验视频

Updated: Jun 24, 2026

Author Spotlight: Nuclei Isolation from Mouse Cardiac Progenitor Cells for Epigenome and Gene Expression Profiling at Single-Cell Resolution
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单核和空间转录形状的健康人腿筋肌的单核和空间转录形状.

Jolet Y Mimpen1, Lorenzo Ramos-Mucci1, Claudia Paul1

  • 1The Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|May 14, 2024
PubMed
概括

健康的人类腿筋肌具有多种细胞类型,包括意想不到的肌肉和神经细胞. 纤维细胞是肌健康和功能的关键,调节细胞外基质和组织平衡.

关键词:
纤维细胞的细胞.腿筋 腿筋 腿筋单个核的转录学 编译学这是骨肌肉的骨架肌肉.空间转录学 空间转录学肌 肌是一种肌.

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Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans
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Author Spotlight: Nuclei Isolation from Mouse Cardiac Progenitor Cells for Epigenome and Gene Expression Profiling at Single-Cell Resolution
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Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
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Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans
05:59

Author Spotlight: Deciphering the Cellular Mysteries of Intermuscular Adipose Tissue in Humans

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科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 生物医学科学 生物医学科学

背景情况:

  • 健康人肌的细胞组成和分子基础尚未得到充分理解.
  • 人类腿筋肌表现出较低的病理,作为健康肌组织的模型.

研究的目的:

  • 为了全面识别和绘制健康的人类腿筋肌内的所有细胞类型.
  • 为了阐明这些细胞的转录组和空间分布.
  • 分析细胞相互作用和调节网络,控制肌平衡.

主要方法:

  • 单核RNA测序 (snRNA-seq) 在来自四位健康捐赠者的10533个核上进行.
  • 空间转录学和先进的成像技术被用来定义细胞位置.
  • 进行生物信息分析以确定细胞类型和转录网络.

主要成果:

  • 在健康的腿筋肌中发现了12种不同的细胞类型.
  • 确定的细胞类型包括纤维细胞,内皮细胞,壁细胞和免疫细胞.
  • 在肌中发现的新型细胞类型包括骨肌细胞,卫星细胞,脂肪细胞和神经系统细胞.
  • 纤维细胞分布在整个肌中,是细胞外基质的生产和组织的核心,这表明纤维细胞在平衡中发挥着关键作用.

结论:

  • 健康的人类肌具有超出传统理解的复杂细胞组成.
  • 纤维细胞被确定为腿筋肌同居的关键调节者.
  • 这些发现提供了对健康肌生物学和细胞相互作用的基本理解.