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通过能量层预选和过后进行高效的质子弧优化和传递

Sophie Wuyckens¹, Viktor Wase², Otte Marthin²

¹UCLouvain, Institut de recherche expérimentale et clinique, Molecular Imaging and Radiation Oncology Laboratory, Brussels, Belgium.

Medical physics

|May 14, 2024

概括

质子弧疗法 (PAT) 的新混合方法可显著缩短口腔癌的治疗时间,最多可减少22%. 这种方法优化了能量层的选择和过,而不影响计划质量,提高了患者的吞吐量.

科学领域:

医学物理医学物理
辐射瘤学辐射瘤学
癌症治疗方法癌症治疗方法

背景情况:

与传统的质子弧疗法相比,质子弧疗法 (PAT) 提供了更好的剂量分配和更快的输送速度.
当前的PAT算法往往无法实现显著的加快速度,有时会增加交付时间.

研究的目的:

为了尽量减少 PAT 交付时间,使用混合方法结合基于几何的能量层 (EL) 预选择和基于剂量的 EL 过.
将这种混合方法的性能与没有过的基线方法进行比较.

主要方法:

开发了三个EL过方法:无限制,切换 (SU) 和切换间隙 (SU).
集成过器与RayStation动态质子弧优化框架的ELSA.
评估方法使用八名癌症患者 (四名口腔,四名肺癌) 的数据,评估计划质量和交付时间与强度调制质子疗法 (IMPT) 相比.

主要成果:

在保持计划质量的同时,SU空隙过方法将交付时间缩短了高达22% (口腔喉) 和15% (肺部).
不受限制的过也显著减少了时间;SU过的影响有限.
目标覆盖率保持稳健 (在1%的变化范围内),风险器官的剂量是可比的或下降.

结论:

开发的方法可以在不影响计划质量的情况下加速PAT交付.
进步可以提高放射瘤学的治疗效率和患者吞吐量.

关键词:

优化的优化优化优化.质子弧疗法是一种质子弧疗法.治疗计划治疗计划

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