芬兰系统性硬化症患者死亡的原因和预测因素
S Kortelainen1,2, M Käyrä3, T Rissanen4
1Centre for Rheumatology and Clinical Immunology, Division of Medicine, Turku University Hospital, Turku, Finland.
Scandinavian journal of rheumatology
|May 14, 2024
概括
系统性硬化 (SSc) 本身是芬兰患者的主要死亡原因,特别是在扩散形式. 间歇性肺病和发病时的年龄较大是SSc.死亡率的关键预测因素.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 系统性硬化症 (SSc) 是一种慢性自身免疫性疾病,其特征是纤维化,血管异常和免疫失调.
- 了解SSc中的死亡模式对于改善患者的治疗结果和临床管理至关重要.
研究的目的:
- 调查芬兰诊断为全身性硬化症的患者死亡的原因和预测因素.
- 分析SSc队列中的生存率和确定与死亡率相关的因素.
主要方法:
- 在两个芬兰大学医院,从1996-2018年对313名SSc患者 (ICD-10代码M34) 的医疗记录进行了回顾性审查.
- 数据收集包括到2020年的临床信息和到2021年8月的死亡证明.
- 统计分析以确定死亡时的平均年龄,诊断时间和死亡率预测因素.
主要成果:
- 在2000年至2020年期间,共有91人死亡,5年和10年生存率分别为88.4%和80.2%.
- 系统性硬化症是35名患者的主要死亡原因;间歇性肺病 (ILD) 是最常见的SSc相关原因 (13例死亡).
- 由于SSc而死亡的患者明显年轻 (平均年龄65.6岁),而不是因其他原因而死亡的患者 (74.2岁). 肺动脉高血压,胃肠道干扰,男性性别,在发病时的年龄较大预测死亡.
结论:
- 系统性硬化症是芬兰患者中疾病的扩散性和有限性皮肤形式的主要死亡原因.
- 间歇性肺病和其他器官特异性并发症显著导致SSc相关的死亡.
- 识别ILD和发病时年龄较大等预测因素对于有针对性的干预和改善SSc的预后至关重要.
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