短期的食纤维干预在研究中产生一致的肠道微生物群反应
Cynthia I Rodriguez1, Kazuo Isobe2, Jennifer B H Martiny1
1Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA.
mSystems
|May 14, 2024
概括
食纤维摄入量始终改变了健康个体的肠道微生物组合. 对16S rRNA数据的重新分析显示,在多项研究中,细菌对纤维消耗增加的反应得到了保护.
科学领域:
- 微生物组研究 微生物组研究
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 人体肠道微生物组的组成在个体之间有很大差异.
- 食纤维对肠道健康至关重要,但它对微生物群的影响在研究中报告不一致.
- 个体间的变化和干预特点 (纤维类型,研究持续时间,队列大小) 导致结果的变化.
研究的目的:
- 在健康个体中确定肠道微生物组对食纤维干预的一致,平均反应.
- 利用现有的16S rRNA测序数据的元分析来克服个别研究的局限性.
主要方法:
- 重新分析了12项人类研究中的21项食纤维干预的16S rRNA测序数据.
- 包括来自538名受试者的2564个便样本.
- 统计分析以确定一致的细菌社区转移和特定类型的反应.
主要成果:
- 饮食纤维的短期增加导致了高度一致的肠道细菌社区反应.
- 纤维摄入量解释了1.5%的组成变化,而个体变化占82%.
- 阿尔法多样性减少,并且观察到细菌相对丰度中的基因组学上保存的反应.
结论:
- 饮食纤维干预引起了一致的肠道微生物群反应,尽管具有很高的个体间变异性.
- 在属级别上,特定的细菌种群在增加纤维摄入量时,相对丰度会持续增加或减少.
- 从多项研究中合成微生物组数据是一种强大的方法,以确定可概括的发现.
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