腹部US在肝细胞癌监测中的未来作用
Mishal Mendiratta-Lala1, David Fetzer1, Aya Kamaya1
1From the Departments of Radiology (M.M.L.) and Internal Medicine (N.D.P.), University of Michigan, Ann Arbor, Mich; Department of Radiology (D.F.) and Department of Internal Medicine, Division of Digestive and Liver Diseases (A.G.S.), University of Texas Southwestern Medical Center, 5959 Harry Hines Blvd, Ste 420, POB 1, Dallas, TX 75390-8887; and Department of Radiology, Stanford University School of Medicine, Stanford, Calif (A.K.).
Radiology
|May 14, 2024
概括
腹部超声波是肝细胞癌 (HCC) 查的主要方法,但它有局限性. 新的成像和血液测试显示,对高危患者个性化HCC监测有前途.
科学领域:
- 肝细胞癌 (HCC) 的监测监测
- 在瘤学中进行诊断成像.
背景情况:
- 腹部超声波 (US) 是风险人群中肝细胞癌 (HCC) 最有效的监测策略.
- 虽然有效,但美国有局限性,包括运营商依赖性和特定人群的敏感性降低,例如肥胖或非病毒性肝病患者.
研究的目的:
- 审查目前HCC监测策略的现状.
- 探索基于成像和基于血液的新兴监控方法.
- 讨论对HCC的精确查的未来.
主要方法:
- 对HCC监测方式的当前文献的审查.
- 分析不同测试的验证阶段和性能特征.
- 讨论新兴技术,如缩短的MRI和生物标志物面板.
主要成果:
- 腹部US表现出对HCC检测的高灵敏度和特异性,特别是在高体积的中心.
- 像缩短的MRI和生物标记面板这样的新兴策略在早期研究中显示出有前途的测试性能.
- 在肥胖或非病毒性肝病患者中,美国的敏感性较低.
结论:
- 预计将转向精确的HCC查,根据患者个体特征量身定制.
- 虽然美国仍然很重要,但随着新监控技术的出现,其作用可能会减少.
- 个性化方法是必要的,以克服当前适合所有HCC监测的局限性.
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