HLA-C*07与症状性HIV-1相关的神经认知障碍 (HAND) 和免疫失调有关
Eduardo Pons-Fuster1, Enrique Bernal2, Concepción F Guillamón1
1Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
Infectious diseases (London, England)
|May 14, 2024
概括
这种HLA-C*07基因变异与抗逆转录病毒治疗患者的症状性HIV-1相关神经认知障碍 (HAND) 有关. 这一遗传因素与免疫细胞衰老的增加相关,影响T细胞的特征.
科学领域:
- 免疫遗传学 免疫遗传学
- 神经免疫学 神经免疫学
- 艾滋病毒 医学 艾滋病毒 医学
背景情况:
- 尽管有抗逆转录病毒疗法 (ART),但HIV-1相关的神经认知障碍 (HAND) 由于免疫失调和炎症而持续存在.
- 人类白细胞抗原 (HLA) I 类等位基因,HLA-C*07,被认为是 HAND 发育的潜在贡献因素.
研究的目的:
- 调查杀手细胞免疫球蛋白类受体 (KIR),HLA配置文件和免疫标记与HAND在稳定的HIV-1患者中之间的关联. 在ART.
- 确定HLA-C*07在HAND病变发生过程中的作用.
主要方法:
- 这是一项对96名HIV-1患者进行的观察性横截面研究,这些患者有或没有HAND.
- 使用SSO-Luminex类型的HLA和KIR基因型的评估.
- 免疫激活和衰老标志物的流细胞计分析,包括CD8+CD28-T细胞和CD8+CD28+T细胞.
主要成果:
- 与无症状HAND相比,症状HAND的患者中HLA-C*07等位基因显著更频繁 (12.0%对2.2%).
- 患有两个副本HLA-C*07的患者表现出更高的衰老CD8+CD28-T细胞百分比.
- 在有症状的HAND中,增加的HLA-C*07拷贝数与非衰老的CD8+CD28+T细胞相反相关.
结论:
- 对HLA-C*07全型的同胞性与症状性HAND有关,可能导致神经认知并发症.
- 两个HLA-C*07副本的存在与一种免疫衰老的T淋巴细胞特征相关,其特征是CD28下调.
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