光学连贯断层扫描血管造影表明多发性硬化症和Sjögren综合征中的不同视网膜病理
Elisabeth Wolf1, Rebecca Wicklein1, Lilian Aly1
1Department of Neurology, Klinikum Rechts Der Isar, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Journal of neurology
|May 14, 2024
概括
视网膜深层血管稀缺性与复发性复发性硬化症 (RRMS) 相比,具有独特的特征,主要是Sjögren综合征 (pSS),并影响视觉功能. 光学连贯断层扫描血管造影 (OCTA) 可能有助于区分这些情况.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 视网膜血管变化已知在复发性复发性多发性硬化症 (RRMS) 中存在.
- 初级斯乔格伦综合征 (pSS) 的血管变化,模仿MS,是不太了解的.
- 光学连贯断层扫描血管造影 (OCTA) 正在探索如何区分RRMS和pSS.
研究的目的:
- 在RRMS和pSS患者中使用OCTA调查视网膜血管变化.
- 使用OCTA发现区分RRMS和pSS.
- 为了将OCTA参数与视觉功能和血清标志物相关联.
主要方法:
- 一项涉及36名RRMS患者,36名pSS患者和30名健康对照者的横截面研究.
- 进行了视网膜OCT和OCTA成像.
- 评估了临床检查,视力敏度和血清标志物;眼睛有视神经炎史被排除在外.
主要成果:
- 与对照组相比,RRMS患者表现出质细胞和内状层的稀薄.
- 无论是RRMS还是pSS患者都表现出降低了表面血管复合体 (SVC) 密度.
- 深血管综合体 (DVC) 稀缺症在pSS患者中观察到,但不是RRMS患者,与视力敏度相关.
结论:
- 深视网膜血管稀缺是PSS的一个明显特征,与RRMS不同.
- 根据视网膜血管病理学,OCTA有可能区分RRMS和pSS.
- 研究结果表明,在RRMS和pSS的视网膜中存在差异性质血管复合体.
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