血清凝血参数与慢性腹腔内血瘤复发之间的关系
1Department of Neurosurgery, The Fourth affiliated Hospital of Soochow University, Suzhou, 215123, Jiangsu, China.
Molecular and cellular biochemistry
|May 14, 2024
概括
住院治疗前纤维素/纤维素降解产物 (FDP) 和D-二聚物 (D-D) 水平升高预测慢性体内血瘤 (CSDH) 复发,特别是在手术后30天内. 建议对老年CSDH患者进行密切监测.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 慢性亚皮血瘤 (CSH) 是一种常见的神经外科疾病.
- 在患者管理方面,CSH的复发带来了重大挑战.
- 对CSH复发的预测标记对于优化治疗策略至关重要.
研究的目的:
- 为了研究入院前血清凝血参数与CSH复发之间的关联.
- 确定CSH复发的新型预测因子,特别是早期的术后复发.
- 评估D-二聚体 (D-D) 和纤维素/纤维素降解产物 (FDP) 的联合预测值.
主要方法:
- 追溯分析236名首次CSH患者的完整医疗记录.
- 随访至少90天,以评估复发率.
- 对一般,成像和实验室数据的单变分析,包括PT,APTT,D-D和FDP水平.
主要成果:
- 在21.2%的患者中观察到CSH复发.
- 显著的复发预测因素包括晚年,高血压,肝病,抗凝剂/抗血小板药物使用,双边和单层血瘤.
- 升高的FDP (>5 mg/L) 和联合升高的D-D和FDP水平显著与CSH复发有关,特别是在手术后30天内.
结论:
- 入院时的血清FDP和D-D水平是CSH复发的潜在新型预测因素.
- 同时提高FDP和D-D可能表明早期术后复发的风险更高.
- 接受手术的老年CSH患者需要密切监测,因为复发率更高.
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