线粒体呼吸在子宫内生长受限制的胎儿羊心脏中较低
Eileen I Chang1, Jane Stremming1, Leslie A Knaub2,3
1Department of Pediatrics, Section of Neonatology, Perinatal Research Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
The Journal of physiology
|May 14, 2024
概括
胎儿羊的子宫内生长限制 (IUGR) 损害了心脏线粒体的能量生产,显示出较低的呼吸和脂质代谢基因表达. 这表明心脏成熟的延迟和成人心血管疾病风险的增加.
科学领域:
- 心血管生物学 心血管生物学
- 线粒体生理学线粒体生理学
- 胎儿的发育 胎儿的发育
背景情况:
- 宫内生长限制 (IUGR) 的胎儿面临成人心血管疾病的更高风险.
- 心肌细胞成熟涉及线粒体基质偏好的转变,从碳水化合物到脂质.
- 减少的线粒体容量可能是IUGR个体心脏病风险增加的基础.
研究的目的:
- 为了研究IUGR胎儿心脏对线粒体氧化酸化的能力有所降低的假设.
- 为了比较IUGR中的线粒体功能和基质利用率与对照胎儿羊心.
- 探索心脏线粒体新陈代谢在IUGR胎儿的左心室和右心室之间的差异.
主要方法:
- 从怀孕晚期的IUGR和对照胎儿羊中采集了左心室和右心室.
- 用碳水化合物和脂质基质测量线粒体呼吸速率.
- 评估了氧化酸化复合物的酸盐合成酶活性和蛋白质表达 (CI-CV).
- 量化了线粒体生物发生调节器和脂质代谢基因的mRNA水平.
主要成果:
- 与对照组相比,IUGR胎儿心在碳水化合物和脂质氧化方面表现出较低的线粒体呼吸率.
- 在 IUGR 左心室中,酸盐合成酶活性降低.
- 虽然一些氧化酸化复合蛋白水平 (CII,CV) 在IUGR中较高,但参与脂质代谢的基因表达较低.
- 观察到明显的室内氧气流和基因表达的差异,独立于IUGR状态.
结论:
- IUGR胎儿心脏显示代谢成熟受损,线粒体呼吸能力和脂质氧化能力下降.
- 特定线粒体蛋白质复合体的升级可能是ATP生产的补偿机制.
- 这些发现突显了IUGR中心脏代谢的脆弱特征,可能导致成人心血管疾病.
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