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相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

417
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
417
Gene-Environment Interactions01:20

Gene-Environment Interactions

298
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
298
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K

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相关实验视频

Updated: Jun 26, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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环境和系统性红血性狼

Chiara Cardelli1, Dina Zucchi1, Elena Elefante2

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.

Clinical and experimental rheumatology
|May 14, 2024
PubMed
概括

环境因素显著影响系统性红斑狼 (SLE) 的发展和活动. 本综述总结了关键数据,即外部触发因素如何影响遗传敏感个体的SLE发病率和疾病进展.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 环境健康 环境健康
  • 类风湿病学 类风湿病学

背景情况:

  • 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病.
  • 它的发病包括遗传,表观遗传和环境因素的复杂相互作用.
  • 环境触发因素在SLE发展和进展中的确切作用仍然不完全理解.

研究的目的:

  • 审查当前对影响SLE的环境因素的理解.
  • 探索环境暴露对SLE发病率的影响.
  • 评估环境因素对被诊断为SLE患者的疾病活动和损伤的影响.

主要方法:

  • 对环境因素和SLE进行了全面的文献搜索.
  • 综合流行病学研究和临床观察数据.
  • 分析环境触发因素与SLE病原体之间的关系.

主要成果:

  • 环境因素与引发SLE免疫功能障碍有关.
  • 特定的环境暴露与SLE发病率的增加有关.
  • 环境影响影响SLE患者的疾病活动和长期损伤.

结论:

  • 环境因素在SLE的多因素病因学中起着至关重要的作用.
  • 了解这些触发因素对于SLE预防和管理策略至关重要.
  • 需要进一步的研究来阐明对SLE的特定环境影响.