血液生物标志物用于职业手臂振动暴露
Per Vihlborg1, Oscar Lundberg2, Paul Pettersson-Pablo3
1Department of Geriatrics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Toxicology and industrial health
|May 14, 2024
概括
职业手臂振动暴露会改变特定的生物标志物. 振动白指 (VWF) 与内甲蛋白-1 (ET-1),素和巨细胞衍生化学激素 (MDC) 度的变化有关,这表明它们在VWF病理生理学中的作用.
科学领域:
- 职业医疗 职业医疗 职业医学
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 手臂振动 (HAV) 是一种普遍的职业危险,导致神经和血管问题,包括振动白手指 (VWF).
- 导致VWF的确切病理机制尚不清楚,提出的理论涉及免疫反应和神经功能障碍.
- 识别可靠的生物标志物可以阐明VWF的病原体,并有助于早期检测.
研究的目的:
- 在职业手臂振动暴露之前和之后,研究特定血清生物标记物介质素-33 (IL-33),巨细胞衍生化学因子 (MDC),介质素-10 (IL-10),内甲素-1 (ET-1),C-C动机化学因子连接体20 (CCL20),素和血栓素 (TXA2) 的变化.
- 为了确定这些生物标志物变化是否在VWF和没有VWF的工人之间有所不同.
主要方法:
- 招募38名全职轮班工人,这些轮班工人暴露于手臂振动.
- 医疗检查以评估雷诺现象的症状.
- 在工作轮班前后对29名参与者的IL-33,MDC,IL-10,ET-1,CCL20,calcitonin和TXA2的血清度进行测量.
主要成果:
- 在轮班后,所有参与者都观察到内甲素-1 (ET-1) 和素度的显著增加,CCL20度的下降.
- 与非VWF组相比,在VWF组的工作轮班前,巨细胞衍生化学激素 (MDC) 水平明显较低 (p = .023).
- 维多利亚工业联合会 (VWF) 集团在轮班工作后,MDC度显著增加.
结论:
- 职业手臂振动暴露与ET-1,素和MDC水平的显著变化有关.
- 这些生物标志物变化,特别是在MDC中,似乎与振动白指 (VWF) 特别相关.
- 这些发现表明,ET-1,calcitonin和MDC可能在振动白指的病理生理学中发挥作用.
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