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环境颗粒物物质与母亲甲状腺自身免疫和早期怀孕时甲状腺功能的关联
Enjie Zhang1, Zheng Zhang1, Gongbo Chen2
1Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
在怀孕早期暴露于细颗粒物 (PM) 与母亲的甲状腺功能障碍有关. 增加PM2.5和PM1-2.5暴露会增加甲状腺自身免疫的风险,并改变甲状腺激素水平.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 孕产妇的甲状腺功能对胎儿发育至关重要.
- 空气污染,特别是颗粒物 (PM),是一个日益严重的环境问题.
- 不同的PM大小部分对孕早期母亲甲状腺健康的影响需要进一步调查.
研究的目的:
- 评估暴露于PM2.5,PM1-2.5和PM1与母亲甲状腺自身免疫之间的关联.
- 在怀孕早期评估PM暴露与母亲甲状腺功能标志物 (FT4,TSH) 之间的关系.
主要方法:
- 预期出生队列研究,包括中国15664名孕妇 (2018-2020年).
- 对PM2.5,PM1-2.5和PM1在怀孕6周至13周+6周期间的暴露评估.
- 使用广义线性模型 (GLMs) 对甲状腺自身免疫和功能进行统计分析.
主要成果:
- 增加的PM2.5和PM1-2.5暴露与母亲甲状腺自身免疫的更高风险显著相关.
- 暴露于PM2.5和PM1-2.5与较低的自由甲状腺素 (FT4) 水平相关;PM1在32.13μg/m3以上显示出负相关性.
- 暴露于PM2.5与提升的甲状腺激素 (TSH) 水平正相关.
结论:
- 在怀孕早期暴露于细颗粒和粗颗粒物与母亲的甲状腺自身免疫有关.
- 空气污染有助于孕妇甲状腺激素水平的改变.
- 这些发现凸显了PM暴露对母亲甲状腺健康的潜在不良影响.
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