相关实验视频

Updated: Jun 26, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

18.5K

TransFOL:用于药物相互作用中的复杂关系推理的逻辑查询模型

Junkai Cheng, Yijia Zhang, Hengyi Zhang

    IEEE journal of biomedical and health informatics
    |May 14, 2024
    PubMed
    概括

    这项研究介绍了TransFOL,一种用于预测药物相互作用 (DDI) 的新型深度学习模型. TransFOL利用知识图和先进的神经网络来提高DDI预测的准确性,并纳入复杂的生物医学因素.

    更多相关视频

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions07:40

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

    Published on: May 27, 2021

    4.2K
    Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System05:10

    Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

    Published on: December 11, 2016

    9.6K

    相关概念视频

    Drug-Receptor Interactions01:29

    Drug-Receptor Interactions

    Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
    Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
    5.1K
    Agonism and Antagonism: Quantification01:14

    Agonism and Antagonism: Quantification

    When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
    To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
    365
    Quantitative Aspects of Drug-Receptor Interaction01:30

    Quantitative Aspects of Drug-Receptor Interaction

    The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
    974
    Pharmacokinetic Models: Overview01:20

    Pharmacokinetic Models: Overview

    Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
    There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
    665
    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

    Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
    A recent model describes pravastatin's hepatobiliary excretion,...
    38
    Drug-Receptor Interaction: Antagonist01:28

    Drug-Receptor Interaction: Antagonist

    An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
    Antagonists can be classified as competitive or noncompetitive based on their...
    2.9K