MTHFR 677 C > T 基因多态性与孕期婴儿大与小相关
Raziye Akcılar1, Emine Esin Yalınbaş2, Fezan Mutlu3
1Faculty of Medicine, Department of Physiology, Kütahya Health Sciences University, Kütahya, Turkey.
Fetal and pediatric pathology
|May 14, 2024
概括
甲基四叶酸减少酶 (MTHFR) 基因变异与婴儿出生体重较高有关. 这种MTHFR 677C>T多态可能表明孕期大婴儿的风险更高.
科学领域:
- 遗传学 是一个遗传学.
- 新生儿健康 新生儿健康
- 分子生物学分子生物学
背景情况:
- 调查甲基二甲基四基叶酸减少酶 (MTHFR) 677C>T基因多态性.
- 检查其与产期婴儿出生大小的关联:小 (SGA),适当 (AGA) 和大 (LGA) 对于妊娠年龄.
研究的目的:
- 为了确定MTHFR 677C>T基因多态化在期婴儿中的作用.
- 评估MTHFR基因型与出生体重类别 (SGA,AGA,LGA) 之间的关联.
主要方法:
- 在165名新生儿中,MTHFR 677C>T多态性的基因定型.
- 从外围血液样本中分离DNA.
- 用于基因定型的聚合酶连锁反应-限制片段长度多态化 (PCR-RFLP) 技术.
主要成果:
- 在AGA,SGA和LGA组之间观察到基因型和等位基因分布的显著差异.
- 与CC和CT基因型相比,具有MTHFR 677 TT基因型的新生儿的出生体重较高.
- 与AGA婴儿相比,MTHFR 677 TT基因型和T等位基因更频繁,并且与LGA婴儿的风险增加有关.
结论:
- MTHFR 677C>T基因多态性可以作为鉴定土耳其婴儿的遗传标记,这些婴儿对于妊娠年龄 (LGA) 很大.
- 没有发现这种多态性是妊娠年龄 (SGA) 婴儿小的显著标志物.
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