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Updated: Jun 26, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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Published on: August 28, 2016

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与疾病相关的PGM1蛋白质变体的破坏稳定和退化

Frederik Gouliaev1, Nicolas Jonsson1, Sarah Gersing1

  • 1Department of Biology, University of Copenhagen, Ole Maalo̷es Vej 5, DK2200N Copenhagen, Denmark.

Biochemistry
|May 14, 2024
PubMed
概括

与PGM1相关的血糖化先天性障碍 (PGM1-CDG) 变体通常不稳定且迅速降解. 这项研究揭示了陪伴者依赖,并确定了许多破坏稳定的PGM1变异,有助于解释疾病机制.

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