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相关概念视频

Fischer Projections02:18

Fischer Projections

13.2K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines.
13.2K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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相关实验视频

Updated: Jun 26, 2025

An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production
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An Efficient and Flexible Cell Aggregation Method for 3D Spheroid Production

Published on: March 27, 2017

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在填充空间的细胞聚合物中绘制图形拓变换.

Tanmoy Sarkar1, Matej Krajnc1

  • 1Department of Theoretical Physics, Jožef Stefan Institute, Ljubljana, Slovenia.

PLoS computational biology
|May 14, 2024
PubMed
概括

我们介绍了图形顶点模型 (GVM) 来模拟组织中的细胞重排. 这种新方法使用图形转换来进行可重复的3D细胞模拟,将2D T1转换概括起来.

科学领域:

  • 计算生物学 计算生物学
  • 生物物理学的生物物理.
  • 组织工程是组织工程.

背景情况:

  • 细胞重组驱动组织变形,但很难在3D中建模.
  • 现有的3D顶点模型是复杂的,缺乏可重现性.

研究的目的:

  • 重构3D顶点模型以更容易实现和可重复性.
  • 在2D和3D组织结构中概括细胞重新排列机制.

主要方法:

  • 开发了使用知识图和图形转换的图形顶点模型 (GVM).
  • 在使用Neo4j图形数据库的Python包中实现GVM.
  • 应用GVM来研究3D细胞聚合物中的顺序-混乱过渡.

主要成果:

  • 通过图形转换,GVM简化了细胞重排模拟.
  • GVM将2D T1转换概括为3D细胞包装.
  • 在3D细胞聚合物中观察到有效的排序,靠近顺序-混乱过渡点.

结论:

  • 知识图为组织拓学提供了一个自然而合适的数据模型.
  • 通过GVM,可以对细胞重组进行可复制和透明的分析.

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Analysis of Astrocyte Territory Volume and Tiling in Thick Free-Floating Tissue Sections
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Analysis of Astrocyte Territory Volume and Tiling in Thick Free-Floating Tissue Sections

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相关实验视频

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Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
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Analysis of Astrocyte Territory Volume and Tiling in Thick Free-Floating Tissue Sections
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Analysis of Astrocyte Territory Volume and Tiling in Thick Free-Floating Tissue Sections

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  • 该GVM框架有助于组织数据的结构化存储,分析和操作.