相关实验视频
Updated: May 4, 2026
16:38
Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
16.8K
使用带有反控制的增强生物电子设备精确地传递生物化学物质.
Giovanny Marquez1, Harika Dechiraju2, Prabhat Baniya2
1Applied Mathematics, Baskin School of Engineering, University of California, Santa Cruz, CA, United States of America.
PloS one
|May 14, 2024
概括
精准医学使用生物电子技术进行个性化药物输送. 一个新的自适应控制器有效地管理设备和,提高精密医学应用的处理精度.
科学领域:
- 生物电子学 生物电子学
- 精准医学是一门精准的医学.
- 控制系统工程 控制系统工程
背景情况:
- 精准医学旨在根据个体患者的变化量身定制治疗.
- 生物电子设备为动态治疗个性化提供实时传感和激活.
- 生物电子设备实施的挑战包括性能变化和操作限制,如电压和.
研究的目的:
- 开发和评估用于精密医学中的生物电子设备的增强控制器.
- 解决关闭循环药物输送系统中设备性能变化和和的挑战.
- 为了证明控制器在精确的治疗交付中的有效性,特别是Fluoxetine.
主要方法:
- 开发了一个增强的滑动模式控制器,具有和管理功能.
- 通过使用质子的数学模型进行了体实验.
- 在体外实验中进行了可控的Fluoxetine输送,与PID和ML控制器进行比较.
主要成果:
- 增强的滑动模式控制器表现出令人满意的控制行动,尽管模型的不确定性和和.
- 在体外实验中,在Fluoxetine输送的各种参考信号上显示出一致的性能.
- 控制器在所有试验中保持了接近参考值的电流值,相对误差低于7%.
结论:
- 开发的控制器有效地解决了生物电子设备中的和和变性挑战.
- 这个控制器为精准医学中的药物输送策略提供了可靠的精度.
- 这些发现支持用于增强生物电子治疗应用的先进控制系统的整合.
相关概念视频
01:28Bioreactor Controls-I
94
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly...
94
01:18Bioreactor Controls-II
76
In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the...
76
01:17Microbial Biosensors
88
Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
88