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干眼疾病患者维生素D受体表达低

Antonia Vieira¹, Javiera Meza², Rodolfo Garreton¹

¹Ophthalmology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile ; and.

|May 14, 2024

概括

与健康人相比,患有干眼病 (DED) 的患者在眼睛表面的维生素D受体 (VDR) 表达显著降低. 这种减少的VDR表达与状元相关,这是DED的常见发现.

科学领域:

眼科医生眼科眼科
皮肤病学皮肤病学
免疫学免疫学免疫学

背景情况:

干眼病 (DED) 是一种影响眼睛表面的普遍疾病.
越来越多的人认识到维生素D及其受体 (VDR) 在眼睛表面健康中的作用.
之前的研究还没有在DED患者中广泛研究VDR表达.

研究的目的:

为了比较被诊断患有干眼病 (DED) 的患者与健康对照者的眼睛表面的维生素D受体 (VDR) 表达.
调查VDR表达,眼表面细胞学和DED中状转化症的严重程度之间的关系.

主要方法:

眼表面细胞学和VDR表达的免疫组织化学评估 (VDR H-score) 在DED患者和健康对照组中进行.
用帕帕尼科劳/周期性酸-希夫染色来评估状形质形成症,并根据尼尔森尺度进行分级.
眼部表面疾病指数 (OSDI) 用于量化DED症状严重程度.

主要成果:

与对照组相比,患有DED的患者表现出明显较低的VDR H分数 (11.2 ± 13.9与80.9 ± 56,P = 0.0001).
在74%的DED患者中存在状代谢,而对照组中为0%.
在形形质形成症的严重程度 (尼尔森等级) 和VDR H-score (rs = -0.71,P = 0.0001) 之间发现了反向相关性.

结论:

这项研究是第一个在患有DED的患者中证明 reduced ocular surface VDR表达的研究.
在DED患者中,较低的VDR表达与增加的平形转化症有关.
VDR水平与报告的DED症状严重程度 (OSDI) 不相关.

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