儿科人口中胃肠道症状和COVID-19感染之间的关系:范围审查
Denise Desconsi1, Juliane Pagliari Araujo1, Marcela Demitto Furtado2
1Universidade Estadual de Londrina, Londrina, PR, Brazil.
患有COVID-19的儿童的胃肠道症状与ACE2受体,肠-大脑轴和儿童多系统炎症综合征有关. 识别这些症状有助于临床管理.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- 胃肠道 (GI) 症状在儿童COVID-19病例中越来越多地被识别出来.
- 关联SARS-CoV-2感染与儿童胃肠道表现的潜在机制需要阐明.
研究的目的:
- 系统地绘制有关GI症状与儿童群体中COVID-19之间的关系的现有文献.
- 综合有关COVID-19儿童胃肠道症状病变的现有证据.
主要方法:
- 根据乔安娜·布里格斯研究所和PRISMA-ScR指南进行了全面的范围审查.
- 在多个数据库 (Embase,PubMed,Scopus等) 进行了搜索. 在2023年7月至8月之间.
- 包括标准包括任何语言的原创研究,全文可用.
主要成果:
- 包含了10项研究,突出了三个关键前提.
- 血管激素转化酶2 (ACE2) 受体,对于病毒的进入至关重要,存在于儿科胃肠道.
- 胃肠道症状与通过肠-大脑轴的压力和感染有关,并且可能是儿童多系统炎症综合征 (MIS-C) 的特征.
结论:
- 该审查确定了三个核心假设,解释了小儿COVID-19中胃肠道症状的起源.
- 识别这些胃肠道症状对于影响儿童的有效临床评估,管理和治疗策略至关重要.
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