β-Caryophyllene对利波多糖诱导的全身炎症的血管张力协同作用
Hugo Alejandro Espinoza-Gutiérrez1, Sofía Cecilia López-Salido1, Mario Eduardo Flores-Soto2
1Laboratorio de Investigación y Desarrollo Farmacéutico, Departamento de Farmacología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, 44430, Guadalajara, Jalisco, Mexico; Laboratorio de Neurobiología Celular y Molecular, División de Neurociencias, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano Del Seguro Social, 44340, Guadalajara, Jalisco, Mexico.
Biochemical and biophysical research communications
|May 14, 2024
概括
饮食中的植物性大麻素β-Caryophyllene表现出血管增生效应,调节Renin-Angiotensin系统 (RAS) 以减少炎症和压力激素. 这项研究强调了其作为抗炎药物的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 氨酶系统 (RAS) 通过不同的轴调节血压和炎症.
- 一个促进炎症的轴涉及氨酸/氨酸受体 ((P) RR),而一个抗炎症的轴包括ACE2/Angiotensin-(1-7) /MasR.
- 植物化学物质可以影响RAS,但植物性大麻素的血管张力协同作用,特别是β-Caryophyllene的作用,仍未得到充分研究.
研究的目的:
- 为了研究β-Caryophyllene对炎症和压力的血管张力协同作用.
- 为了探索β-Caryophyllene如何调节Renin-Angiotensin系统 (RAS) 的关键组成部分.
- 评估β-Caryophyllene对炎症标志物和压力激素的影响.
主要方法:
- 在内利波聚糖 (LPS) 给药后,小鼠接受了口服β-Caryophyllene的治疗.
- 测量了雷宁,ACE2和 ангиотензин-1-7的血清度和活性.
- 测量了皮质和促炎/抗炎细胞因子的水平.
主要成果:
- 治疗β-Caryophyllene增加了Renin和Angiotensin-(1-7) 的水平.
- 观察到促炎性细胞因子和皮质的显著降低.
- 这些变化表明由β-Caryophyllene对宁-氨系统 (RAS) 的调节.
结论:
- β-Caryophyllene表现出血管张力协同活性,有利于抗炎途径.
- 这项研究表明β-Caryophyllene可以缓解系统性炎症和压力.
- β-Caryophyllene具有作为一种治疗剂的潜力,其向的是Renin-Angiotensin系统 (RAS).
相关概念视频
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
715
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
715
01:26Adrenergic Receptors: β Subtype
1.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.6K
01:17Antihypertensive Drugs: Action of β1 Blockers
432
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
432
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
620
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
620
01:09GPCRs Regulate Adenylyl Cylase Activity
5.5K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.5K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
422
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
422