登革热患者发烧的持续时间:系统性审查和元分析
Nitin Gupta1,2, Carl Boodman1,3, Christelle Genevieve Jouego2,4
1Department of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
概括
登革热通常持续5.1天. 对于发烧持续时间低于5.5天的登革热患者,抗生素可能是不必要的,除非怀疑同时存在细菌感染.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 登革热是一种热带病毒性疾病,死亡率高.
- 滥用抗生素在登革热中很常见,原因是发烧缓解和害怕二次感染.
研究的目的:
- 为了确定登革热患者发烧的平均持续时间.
- 为登革热管理中使用抗生素提供基于证据的指导.
主要方法:
- 从PubMed和Embase研究的系统审查和元分析到2022年10月.
- 纳入标准:对>20名患者的研究,报告发烧持续时间的平均值和标准偏差.
- 31篇文章 (7,905名患者) 被纳入最终分析.
主要成果:
- 登革热患者发烧的平均持续时间为5.1天 (95% CI:4.7-5.5).
- 发烧持续时间较长与更高的发烧级别,疾病严重程度增加和同时发生的细菌感染有关.
结论:
- 登革热中的发烧通常在5.1天内消失.
- 对于持续不到5.5天的发烧,缺乏细菌病的危险因素的登革热患者来说,抗菌药物可能是不必要的.
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