唐氏综合征中胃肠道异常的患病率和结果
Marwa M Elgendy1, Josef Cortez2, Firas Saker3
1Department of Pediatrics, University of Florida, Jacksonville, Florida.
American journal of perinatology
|May 14, 2024
概括
患有唐氏综合征 (DS) 的婴儿有明显更高的风险发展小肠缩和希尔施普伦格缩.
科学领域:
- 儿科手术 儿科手术
- 医学遗传学 医学遗传学
- 胃肠病学 胃肠病学
背景情况:
- 唐氏综合征 (DS) 与先天性胃肠异常的发病率增加有关.
- 小肠缩和赫施普隆病 (HD) 是重要的先天性胃肠道疾病.
- 这些异常在患有DS的婴儿中同时出现需要进一步调查.
研究的目的:
- 确定患有唐氏综合征 (DS) 的婴儿中小肠缩和赫施普朗格病 (HD) 的患病率.
- 评估这些并发症对婴儿后果的影响.
- 评估与这些异常相关的婴儿死亡风险.
主要方法:
- 分析国家住院样本 (NIS) 数据库.
- 包括被诊断患有唐氏综合征 (DS),小肠缩,赫施普朗格病 (HD) 或两者兼有的婴儿.
- 利用回归分析调整临床和人口变量.
主要成果:
- 总共有66,213,034名婴儿被分析,其中99,861名 (0.15%) 患有DS.
- 小肠缩和HD的联合发生在患有DS的婴儿中明显高 (aOR: 122,95%CI: 96-154,p < 0.001).
- 患有DS和两种疾病的婴儿的死亡率显著增加 (aOR:8.59,95%CI:1.95-37.8).
结论:
- 患有唐氏综合征的婴儿面临着同时发生小肠缩和赫施普朗格病的风险增加.
- 在患有DS的婴儿中,这种先天性胃肠道异常的组合与更高的死亡风险有关.
- 早期识别和管理对于改善这一弱势群体的结果至关重要.
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