目前的状况和改善药物输送的进展在扩散内在的庞丁质瘤中
Lauren M Arms1, Ryan J Duchatel2, Evangeline R Jackson2
1Therapeutic Targeting Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia; Paediatric Program, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine & Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
概括
扩散的中线结质瘤 (DMG) 和扩散的内在结质瘤 (DIPG) 是侵袭性的儿科脑瘤. 克服血脑屏障 (BBB) 对于有效的药物输送和改善生存率至关重要.
科学领域:
- 神经瘤学神经瘤学
- 儿科瘤学 儿科瘤学
- 药物输送系统是药物输送系统.
背景情况:
- 扩散性中线质瘤 (DMG),包括扩散性内在质瘤 (DIPG),是儿童脑瘤死亡的主要原因,平均存活时间低于12个月.
- 目前的治疗方法,如皮质类固醇和辐射,只能暂时缓解症状,强调需要更有效的治疗方法.
- 血脑屏障 (BBB) 和血脑瘤屏障 (BBTB) 对将治疗药物输送到脑干造成重大障碍,这是DIPG影响的关键区域.
研究的目的:
- 在DIPG的背景下,审查目前对BBB/BBTB的理解.
- 讨论传统治疗的局限性,并探索DIPG的新药输送策略.
- 强调需要更好地对DIPG患者的BBB/BBTB进行表征,以告知未来的治疗发展.
主要方法:
- 在DIPG中对BBB/BBTB进行现有研究的文献综述.
- 对DIPG的传统和新兴治疗方法的分析.
- 讨论旨在克服BBB/BBTB的药物输送技术.
主要成果:
- 在DIPG中,BBB/BBTB的理解很差,这使治疗策略复杂化.
- 传统疗法提供了有限的生存益处.
- 新型药物递送技术,如对流增强递送,聚焦超声波,纳米颗粒介导递送和鼻内递送显示出有前途,但尚未在临床上为DIPG建立.
结论:
- 在DIPG中改善BBB/BBTB的特征对于开发有效的治疗方法至关重要.
- 新的药物输送方法对于提高DIPG的治疗疗效至关重要.
- 需要对先进的药物输送技术进行进一步的研究和临床验证,以改善DIPG的儿科患者的治疗结果.
相关概念视频
01:29Drug Delivery: Parenteral Route
504
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
504
01:22Drug Delivery: Miscellaneous Routes
338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338