来自生物巨分子的水凝的组织再生特性:一篇综述
Payal Kesharwani1, Amit Alexander2, Rahul Shukla3
1Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India; Institute of Pharmacy, Ram-Eesh Institute of Vocational and Technical Education Greater Noida, India.
International journal of biological macromolecules
|May 14, 2024
概括
水凝支架对于组织工程至关重要,提供支持细胞生长和再生的仿生环境. 本综述详细介绍了它们的生产,机制以及在再生各种组织中的各种应用.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 组织工程依赖于先进的支架来支持细胞功能并促进再生.
- 水凝模仿自然的细胞外基质,增强细胞存活和扩散以进行组织修复.
- 脚手架修改 (大小,形状,多孔性) 解决了诸如血管化和多细胞播种等关键挑战.
研究的目的:
- 提供水凝生产方法和机制的全面审查.
- 探索水凝支架在各种组织工程环境中的应用.
- 突出临床研究,专利和当前水凝支架的局限性.
主要方法:
- 对用于凝生产的天然和合成生物材料的审查.
- 对影响组织再生的水凝支架特性进行分析.
- 在心脏,软骨,脂肪,神经和骨组织工程中检查水凝应用.
主要成果:
- 水凝提供可调节的特性,用于优化伪细胞外环境.
- 修改后的水凝支架有助于改善组织结构和血管化.
- 在多种组织类型中展示了多种应用,正在进行临床转化.
结论:
- 水凝支架是多功能且对于推进组织工程至关重要.
- 对凝生产和应用的持续研究对于克服局限性至关重要.
- 基于水凝的策略显示出临床再生医学的重大前景.
更多相关视频
08:50Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
Published on: August 4, 2017
6.7K
10:36Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
Published on: December 9, 2022
6.8K
相关概念视频
Zygotic Development And Stem Cell Formation
6.4K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.4K
Overview of Regeneration and Repair
4.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
4.8K
Whole Body Regeneration
3.6K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.6K
