来自Isodon serra的六种具有抗炎和细胞毒性活性的新型二氧化物
Xiaoying Liu1, Zhiwei Bian1, Yintai Tian1
1School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, China.
Fitoterapia
|May 14, 2024
概括
研究人员从Isodon serra中发现了新型的双虫,这是中国传统医药. 一些化合物显示出显著的抗炎和抗癌活性,突出显示了它们的治疗潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 迪特尔类是一种多样化的自然产品,具有显著的生物活性和复杂的结构.
- 伊索登塞拉是一种广泛使用的传统中医药,具有潜在的治疗应用.
- 探索像I. serra这样的天然产品对于发现新药线索至关重要.
研究的目的:
- 为了隔离和表征来自Isodon serra.新型的四面体.
- 评估隔离化合物的抗炎和细胞毒性活性.
- 研究这些自然产品的结构-活性关系.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过全面的光谱数据分析 (NMR,MS) 阐明结构.
- 使用实验和计算的电子圆二元体 (ECD) 和X射线衍射分析来确认结构.
- 在体外抗炎试验中,使用脂聚糖 (LPS) 诱导的RAW 267.4细胞测量氧化 (NO) 生产.
- 在体外细胞毒性测定对人类细胞癌769P细胞.
主要成果:
- 从Isodon serra.分离出六种新的二甲 (维罗素B-G) 和四种已知的化合物.
- 化合物2,5,7,8和10表现出显著的抗炎活性,在10μM时抑制了超过60%的NO生产.
- 化合物7对人类细胞癌769P细胞表现出显著的细胞毒性,其抑制率在20μM时为52.66%.
结论:
- 这项研究成功地确定了来自Isodon serra的新型二甲,具有有前途的药理特性.
- 隔离的化合物,特别是维罗素,有潜力开发新的抗炎和抗癌疗法.
- 对这些二类药物的进一步研究可能会导致从自然来源获得的新型药物候选物.
更多相关视频
09:20Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
8.4K
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1.5K
相关概念视频
01:29Diels–Alder Reaction: Characteristics of Dienes
4.1K
The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is...
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is...
4.1K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
131
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
131
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
158
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
158