系统性红斑狼的光学连贯性断层扫描血管学测量:一个系统性审查和元分析
Sepehr Fekrazad1, Golnar Hassanzadeh2, Mohammad Amin Salehi2
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; International Network for Photomedicine and Photodynamic Therapy (INPMPDT), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Survey of ophthalmology
|May 14, 2024
概括
光学连贯断层扫描血管造影 (OCTA) 可以检测视网膜微血管变化系统性红斑狼 (SLE) 患者. 这种非侵入性成像可能有助于早期的SLE诊断和疾病监测.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 系统性红斑狼 (SLE) 是一种多系统的自身免疫性疾病.
- 在SLE患者中,包括视网膜病变在内的眼部表现很常见.
- 早期发现眼部并发症对于管理SLE至关重要.
研究的目的:
- 评估光学相干断层扫描血管学 (OCTA) 在检测SLE患者视网膜微血管变化的有效性.
- 评估OCTA作为SLE诊断和疾病活动监测的潜在生物标志物.
主要方法:
- 在PubMed,Embase和Scopus上进行了系统的文献搜索.
- 包括的研究比较了SLE患者的OCTA测量与健康对照.
- 进行了元分析,子组分析,灵敏度分析和元回归.
主要成果:
- 分析了13项涉及565个SLE眼睛和560个对照眼睛的研究.
- SLE患者在表面和深层毛细管中显著减少了视网膜血管密度.
- 在SLE患者中观察到减少的胆管囊流域和FAZ循环度指数.
- 没有发现在骨无血管区 (FAZ) 区域或周围有显著差异.
结论:
- OCTA非侵入性地评估SLE诱导的视网膜微血管变化.
- OCTA显示出作为SLE检测和监测的可靠生物标志物的潜力.
- 进一步的研究可以验证OCTA在SLE管理的临床实践中的作用.
关键词:
深层毛细管复合体深层毛细管复合体状血管区域 (FOVAL AVASCULAR ZONE) 是一个光学连贯性断层扫描血管学视网膜血管系统 视网膜血管系统表面的毛细血管.系统性红斑性狼 红斑性狼 系统性狼更多相关视频
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