意大利SLE流行病学:使用初级保健数据库的观察性研究
Pietro Ferrara1,2, Ippazio C Antonazzo1,2, Manuel Zamparini3
1Center for Public Health Research, University of Milan-Bicocca, Monza, Italy.
Lupus science & medicine
|May 14, 2024
概括
系统性红斑狼 (SLE) 的发病率在意大利正在增加,女性的患病率更高. 年龄,性别和位置等因素显著影响SLE流行病学.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,具有重大的全球健康影响.
- 了解SLE的流行病学趋势对于资源分配和医疗保健规划至关重要.
研究的目的:
- 为了确定意大利SLE的发病率和流行率.
- 描述新诊断的SLE患者的人口和临床特征.
主要方法:
- 一个回顾性队列研究,利用意大利的健康改善网络数据库 (2017-2022).
- 包括634,753个人,使用三种不同的定义识别SLE病例.
- 计算每10万人/年发生率和每10万人/年流行率.
主要成果:
- 在2022年,SLE发病率为6.51/100,000人/年,流行率为60.57/100,000人.
- 与男性相比,女性的患病率明显高 (5倍),自2017年以来,患病率和患病率均呈上升趋势.
- 观察到地理差异,并确定了与慢性病和类风湿关节炎等先前存在的疾病的关联.
结论:
- 这项研究表明,意大利的SLE发病率正在上升.
- 年龄,性别和地理区域是意大利人口中SLE流行病学的关键决定因素.
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