肺癌中的免疫检查点阻塞抵抗:新出现的机制和治疗机会
Jessica M Konen1, Haoyi Wu2, Don L Gibbons3
1Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.
Trends in pharmacological sciences
|May 14, 2024
概括
免疫检查点阻塞 (ICB) 疗法在癌症治疗中表现有前途,但面临阻力. 了解瘤细胞和微环境因素是克服抵抗和推进个性化免疫疗法的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 针对PD-1/PD-L1和CTLA-4等抑制检查点的免疫检查点阻塞 (ICB) 疗法已经改变了癌症治疗.
- 尽管最初取得了成功,但新的ICB药物的临床开发已经放缓,这表明有效性存在挑战.
- 瘤细胞内在和外在的抵抗机制是实现对ICB治疗持续反应的重大障碍.
研究的目的:
- 审查关于瘤细胞对肺癌ICB治疗的内在和外在抵抗机制的最新研究.
- 识别导致ICB耐药性的宿主和微环境因素.
- 探索克服ICB耐药性的不断发展的策略,并开发个性化的免疫治疗方案.
主要方法:
- 关于肺癌中ICB耐药性的最近研究的文献综述.
- 对瘤细胞内在变化的分析 (基因组和非基因组).
- 评估外部因素,包括微生物组,代谢物和缺氧.
主要成果:
- 基因组和非基因组瘤细胞的改变有助于ICB耐药性.
- 宿主因素,如微生物组和微环境因素,如缺氧和代谢物积累,促进免疫抑制.
- 这些不同的因素可以协同增强对ICB治疗的耐药性.
结论:
- 内在和外在的抵抗机制对ICB在肺癌中的有效性构成重大挑战.
- 对这些耐药性因素的全面了解对于改善治疗结果至关重要.
- 未来的方向包括开发个性化免疫治疗策略,以克服ICB耐药性.
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