无形固体分散持续释放配方与聚合物复合物矩阵调节稳定释放高原的开发
Lingwu Chen1,2, Enshi Hu3, Peiya Shen3
1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Pharmaceutical research
|May 14, 2024
概括
使用聚合物复合材料开发稳定的布洛芬 (IBU) 无形固体分散 (ASDs) 创造了一致的药物释放高原. 这种方法最大限度地减少了药物释放的变化,提高了配方的可预测性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 开发无形固体分散 (ASD) 对于改善易布洛芬 (IBU) 等难溶药物的生物可用性至关重要.
- 控制自闭症的药物释放概况对于实现持续的治疗效果和减少剂量频率至关重要.
研究的目的:
- 开发布洛芬 (IBU) 持续释放无形固体分散剂 (ASDs) 使用聚合物复合材料矩阵.
- 为了实现稳定的药物释放高原,并阐明聚合物矩阵比率和药物释放行为之间的关系.
主要方法:
- 通过热挤出,利用水友性和水性聚合物的组合制备IBU ASD.
- 对药物溶解曲线,聚合物膨胀和分子间力量的分析,以了解药物释放机制.
主要成果:
- IBU ASDs 呈现出一种"溶解平原现象",当聚-1-乙烯基烯酸-联合乙烯酸 (PVP VA64) 含量在 35% 至 50% 之间时,释放稳定.
- 药物释放是由PVP VA64介导的溶解和RSPO-PVP VA64组装介导的胀调节的.
- 确定RSPO和PVP VA64之间的类似分子间力量是稳定释放高原的关键.
结论:
- 该研究提供了一种开发ASD持续释放配方的策略,该配方通过聚合物组合具有可预测的释放配置.
- 开发的ASD在过程简单性,可扩展性和良好的药物释放特性方面具有优势.
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