加快的Teta爆发超磁刺激用于自闭症谱系障碍中耐火性抑郁症
Elizabeth Blank1, Donald L Gilbert2, Steve W Wu2
1Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Journal of autism and developmental disorders
|May 14, 2024
概括
加快的甲爆刺激 (ATBS) 在患有自闭症谱系障碍 (ASD) 的人群中有效治疗主要抑郁症 (MDD). 这种治疗显示出显著的症状改善,并且耐受性很好,因此需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 重度抑郁症 (MDD) 经常与自闭症谱系障碍 (ASD) 一起发生,导致严重的损伤.
- 在ASD中治疗MDD通常具有挑战性,治疗抵抗率高.
研究的目的:
- 评估加速甲爆刺激 (ATBS) 的疗效和耐受性,用于治疗ASD成人的耐火性MDD.
- 评估ATBS对该群体抑郁症状,认知和睡眠质量的影响.
主要方法:
- 一个前性的,开放的,为期12周的试验,涉及10名患有ASD和MDD的参与者.
- 参与者在10天内 (每天3次治疗) 接受了背侧前额叶皮层的单边或双边加速甲基突发刺激 (ATBS).
- 使用汉密尔顿抑郁评分表 (HDRS) 和自我报告措施来评估抑郁症状.
主要成果:
- 一名参与者因无法忍受而退出;没有报告严重不良事件.
- 在治疗后观察到HDRS得分的显著和持续下降.
- 50%的参与者实现了完全缓解,12周后30%的参与者实现了部分缓解.
- 在二次结果中也注意到了改善,包括流体认知和睡眠质量.
结论:
- 加快的甲爆刺激 (ATBS) 是一种高效且能很好地治疗自闭症谱系障碍 (ASD) 患者的大型抑郁症 (MDD) 的治疗方法.
- 这些发现支持通过更大规模的假控随机试验进行进一步的研究,以确认ATBS在这个特定人群中的有效性.
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