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Updated: Jul 18, 2026

Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS
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一个简单而高度敏感的LC-MS工作流程,用于ADC可分割的有效载荷的表征和量化

Shi Ya Mak1, Shuwen Chen1, Wey Jia Fong1

  • 1Bioprocessing Technology Institute (BTI), Agency for Science, Technology and Research (A*STAR), Centros, Singapore, 138668, Singapore.

Scientific reports
|May 14, 2024
PubMed
概括

一种新的,敏感的方法使用液态染色体-并联质谱法量化小鼠血清中的六种抗体-药物联合体 (ADC) 有效载荷. 这种经过验证的工作流需要最小的样本量,并且在药理动力学研究中有效.

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相关概念视频

Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...