在糖尿病玻璃切除术后,神经缩性角膜病变的局部胰岛素
Taher K Eleiwa1, Ahmed A Khater2, Abdelrahman M Elhusseiny3,4
1Department of Ophthalmology, Benha University, Benha, Egypt. taher.eleiwa@fmed.bu.edu.eg.
Scientific reports
|May 14, 2024
概括
局部胰岛素 (TI) 在糖尿病玻璃切除术 (DV) 后显著加快神经营养皮质病 (NK) 的愈合速度. 这种安全的治疗方法减少了对胎膜移植 (AMT) 的需要,并促进了角膜上皮的更快愈合.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 再生医学是一种再生医学.
背景情况:
- 神经缩性角膜病变 (NK) 是糖尿病玻璃切除术 (DV) 后的一种严重并发症.
- 传统的NK治疗方法,包括滑剂和抗生素,都有局限性.
- 局部胰岛素 (TI) 对眼睛表面愈合的潜力仍然是一个研究领域.
研究的目的:
- 评估局部胰岛素 (TI) 在治疗神经缩性角质病变 (NK) 的疗效和安全性.
- 为了比较TI治疗与NK糖尿病后玻璃切除术 (DV) 的常规非侵入性措施.
- 评估TI对角膜上皮质愈合时间的影响以及需要胚胎膜移植 (AMT) 的需要.
主要方法:
- 对DV后急性NK (2和3阶段) 患者进行了回顾性病例控制研究.
- 对照组接受了无防腐剂的滑剂眼滴和预防性局部抗生素.
- 研究组除了接受标准护理外,还接受了TI (1单位/滴,每天4次).
主要成果:
- 在TI组中,角膜上皮的愈合明显更快 (平均差异为12.16天,P=0.001).
- 与对照组相比,TI组的治愈失败率较低 (0%第二阶段,20%第三阶段) (20%第二阶段,66.7%第三阶段).
- 没有报告TI的不良影响;两只对照眼睛需要AMT,三只进步的对照在转换到TI后得到改善.
结论:
- 局部胰岛素 (TI) 是一种有效和安全的治疗方法,用于在糖尿病玻璃切除术 (DV) 后促进神经缩性角膜皮质治疗 (NK).
- TI治疗加快了愈合速度,减少了像羊水膜移植 (AMT) 等更具侵入性的手术的需要.
- 这些发现支持使用TI作为DV后NK的有价值的治疗选择.
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