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Updated: Jun 26, 2025

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在人类口腔状细胞癌中由CALML6调解的EP4诱导的线粒体定位和细胞迁移

Soichiro Ishikawa1,2, Masanari Umemura3, Rina Nakakaji1,2

  • 1Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

Communications biology
|May 14, 2024
PubMed
概括

EP4受体激活通过信号传递和增强线粒体功能驱动口腔状细胞癌 (OSCC) 细胞迁移和转移. 向CaMKK2显示出抑制OSCC转移的希望.

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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