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Updated: Jun 26, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Published on: June 12, 2021

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老化的瘤微环境限制了T细胞对癌症的控制

Alex C Y Chen1,2,3,4, Sneha Jaiswal1,5, Daniela Martinez1,2,3,4

  • 1Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.

Nature immunology
|May 14, 2024
PubMed
概括

衰老会通过在瘤微环境 (TME) 中引起CD8+T细胞功能障碍而降低抗瘤免疫力. 这种由TME驱动的与年龄相关的功能障碍阻碍了癌症疫苗的有效性,但可以通过针对骨髓细胞的治疗来克服.

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