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对于异质和菌素中间体黄金葡萄球菌分离物的BHI-V4的诊断值:系统性审查和元分析

Xin Cheng¹, Juntong Zhou¹, Fan Yuan²

¹Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

BMC infectious diseases

|May 14, 2024

概括

大脑-心脏输液芳与万科米辛 (BHI-V4) 显示在检测异质的万科米辛中间体黄金葡萄球菌 (hVISA) 和万科米辛中间体黄金葡萄球菌 (VISA) 中的中等准确性. 需要进一步进行高质量的研究来确认其临床有用性.

科学领域:

微生物学微生物学
临床诊断临床诊断临床诊断
抗微生物耐药性抗微生物耐药性

背景情况:

补充了万科米辛 (BHI-V4) 的脑心输液是一种常见的方法,用于检测异质的万科米辛中间体黄金葡萄球菌 (hVISA) 和万科米辛中间体黄金葡萄球菌 (VISA).
BHI-V4用于识别这些耐药菌株的诊断准确性仍然不确定.
这项研究评估了BHI-V4的诊断性能,与人口分析概况与曲线下的面积 (PAP-AUC) 相比.

研究的目的:

为了比较BHI-V4的诊断准确度与hVISA/VISA检测的PAP-AUC.
提供关于BHI-V4诊断性能现有研究的元分析.

主要方法:

在PubMed和Cochrane图书馆数据库中进行了系统的文献搜索,直到2023年10月.
八个出版物,包括2153个菌株,被纳入了元分析.
使用STATA17.0进行统计分析,使用Review Manager 5.4进行质量评估.

主要成果:

分析显示,所包含的研究之间存在显著的异质性.
总结接收器操作特征 (SROC) 曲线表明诊断准确度的面积为0.77.
聚合灵敏度为0.59,聚合特异性为0.96,诊断几率比为32.62.

结论:

BHI-V4在识别hVISA/VISA时表现出中度的诊断准确性.
需要进行额外的高质量研究,以充分确定BHI-V4.4的临床效用.
这些发现表明,BHI-V4可以成为一种有用的,虽然不完美的,工具,用于诊断Staphylococcus aureus. vancomycin耐药性.

关键词:

在BHI-V4中,我们可以看到BHI-V4.诊断值是一个诊断值.进行元分析分析.系统性审查系统性审查签证签证是一个签证.这是一个hVISASA.

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